Challenges and Pitfalls in the Engineering of Human Interleukin 22 (hIL-22) Secreting Lactobacillus reuteri

Lactobacillus delivery of bioactive interleukin-22

BACKGROUND Interleukin-22 (IL-22) plays a prominent role in epithelial regeneration and dampening of chronic inflammatory responses by protecting intestinal stem cells from immune-mediated tissue damage. IL-22 has a considerable therapeutic potential in graft-versus-host disease (GVHD), which is a frequent and challenging complication following allogeneic stem cell transplantation. The aim of o...

IL 22 ( interleukin 22 )

The Role of Interleukin (IL-22) in immune response to human diseases

Background and aims: IL-22 is an alpha- helical cytokine. IL-22 binds to a heterodimeric cell surface receptor composed of IL-10R2 and IL-22R1subunits. IL-22R is expressed on tissue cells, and it is absent on immune cells. L-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction to selectively initiate and regulate immune responses. The aim of this study was to i...

Antiapoptotic activity of autocrine interleukin-22 and therapeutic effects of interleukin-22-small interfering RNA on human lung cancer xenografts.

PURPOSE Non-small cell lung carcinoma (NSCLC) is one of most common malignant diseases and usually is resistant against apoptosis-inducing chemotherapy. This study is to explore the antiapoptotic mechanisms of interleukin (IL)-22 in human lung cancer. EXPERIMENTAL DESIGN Nineteen cases with stage I to III NSCLC were collected to determine the expression of IL-22. Stable transfection of human ...

the role of interleukin (il-22) in immune response to human diseases

background and aims:il-22 is an α-helical cytokine.il-22 binds to a heterodimeric cell surface receptor composed of il-10r2 and il-22r1subunits.il-22r is expressed on tissue cells and it is absent on immune cells.il-22 and il-10 receptor chains play a role in cellular targeting and signal transduction to selectively initiate and regulate immune responses. the aim of this study was to investigat...